Drug interactions
Ozanimod + Vedolizumab
Severity: Moderate
Ozanimod and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod lowers circulating lymphocytes and vedolizumab limits gut lymphocyte trafficking, so combined use may increase infection risk. The effects of ozanimod persist for weeks after stopping.
What this interaction means in plain words
Ozanimod and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from S1P receptor modulation (lymphocyte sequestration) and alpha4beta7 integrin blockade.
What to do
Monitor for infection and check lymphocyte counts. When transitioning between these agents, account for ozanimod's prolonged lymphocyte effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Vedolizumab?
MediHelp rates the interaction as moderate. Ozanimod and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod lowers circulating lymphocytes and vedolizumab limits gut lymphocyte trafficking, so combined use may increase infection risk. The effects of ozanimod persist for weeks after stopping.
How serious is the interaction between Ozanimod and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check lymphocyte counts. When transitioning between these agents, account for ozanimod's prolonged lymphocyte effects.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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