Drug interactions
Palbociclib + Rucaparib
Severity: Moderate
Palbociclib and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor in vitro and may increase palbociclib exposure. Both drugs cause myelosuppression, so overlapping hematologic toxicity is a concern.
What this interaction means in plain words
Palbociclib and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palbociclib belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing palbociclib metabolism, with additive myelosuppression pharmacodynamically.
What to do
Monitor complete blood counts regularly and reduce the palbociclib dose if neutropenia or other toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Palbociclib with Rucaparib?
MediHelp rates the interaction as moderate. Palbociclib and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP3A4 inhibitor in vitro and may increase palbociclib exposure. Both drugs cause myelosuppression, so overlapping hematologic toxicity is a concern.
How serious is the interaction between Palbociclib and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce the palbociclib dose if neutropenia or other toxicity occurs.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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