Drug interactions
Paliperidone + Tepotinib
Severity: Moderate
Paliperidone and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein, which is involved in the efflux of paliperidone. Paliperidone exposure may rise, increasing dose-related adverse effects such as extrapyramidal symptoms, QT prolongation and orthostasis.
What this interaction means in plain words
Paliperidone and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits intestinal and renal P-gp, reducing paliperidone efflux and clearance.
What to do
Monitor for paliperidone adverse effects such as sedation, extrapyramidal symptoms and hypotension, and reduce the paliperidone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Paliperidone with Tepotinib?
MediHelp rates the interaction as moderate. Paliperidone and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein, which is involved in the efflux of paliperidone. Paliperidone exposure may rise, increasing dose-related adverse effects such as extrapyramidal symptoms, QT prolongation and orthostasis.
How serious is the interaction between Paliperidone and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paliperidone adverse effects such as sedation, extrapyramidal symptoms and hypotension, and reduce the paliperidone dose if they occur.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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