Drug interactions
Paliperidone + Tucatinib
Severity: Moderate
Paliperidone and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone is a P-glycoprotein substrate, and tucatinib inhibits this transporter. Paliperidone exposure may therefore rise, increasing dose-related adverse effects such as sedation, extrapyramidal symptoms and QT prolongation.
What this interaction means in plain words
Paliperidone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibition of intestinal and renal P-glycoprotein efflux, reducing paliperidone clearance and increasing absorption.
What to do
Monitor for increased paliperidone adverse effects and consider a dose reduction if they occur. Review the dose again when tucatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Paliperidone with Tucatinib?
MediHelp rates the interaction as moderate. Paliperidone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone is a P-glycoprotein substrate, and tucatinib inhibits this transporter. Paliperidone exposure may therefore rise, increasing dose-related adverse effects such as sedation, extrapyramidal symptoms and QT prolongation.
How serious is the interaction between Paliperidone and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased paliperidone adverse effects and consider a dose reduction if they occur. Review the dose again when tucatinib is stopped.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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