Drug interactions
Paliperidone + Vilazodone
Severity: Moderate
Paliperidone and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone blocks dopamine and serotonin receptors, and with vilazodone it may rarely precipitate serotonin syndrome or neuroleptic malignant syndrome. Most patients tolerate the pair but the reactions can be serious.
What this interaction means in plain words
Paliperidone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity with dopamine D2 antagonism, a pharmacodynamic interaction.
What to do
Monitor for mental status change, clonus, fever, rigidity and autonomic instability around initiation and dose changes. Stop the drugs and treat supportively if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Vilazodone?
MediHelp rates the interaction as moderate. Paliperidone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone blocks dopamine and serotonin receptors, and with vilazodone it may rarely precipitate serotonin syndrome or neuroleptic malignant syndrome. Most patients tolerate the pair but the reactions can be serious.
How serious is the interaction between Paliperidone and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, clonus, fever, rigidity and autonomic instability around initiation and dose changes. Stop the drugs and treat supportively if toxicity appears.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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