Drug interactions
Panobinostat + Sotalol
Severity: Contraindicated
Panobinostat and Sotalol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and its labeling does not recommend use with other QT-prolonging drugs. Sotalol adds both QT prolongation and bradycardia, increasing the risk of torsades de pointes.
What this interaction means in plain words
Panobinostat and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Panobinostat belongs to Oncology; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Do not combine; use an alternative antiarrhythmic or rate control strategy during panobinostat treatment. If it cannot be avoided, seek specialist input and monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Sotalol?
MediHelp rates the interaction as contraindicated. Panobinostat and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat prolongs the QT interval and its labeling does not recommend use with other QT-prolonging drugs. Sotalol adds both QT prolongation and bradycardia, increasing the risk of torsades de pointes.
How serious is the interaction between Panobinostat and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antiarrhythmic or rate control strategy during panobinostat treatment. If it cannot be avoided, seek specialist input and monitor ECG and electrolytes closely.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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