Drug interactions
Papaverine + Propofol
Severity: Minor
Papaverine and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine is a vasodilator with minimal sedative properties, and propofol also lowers vascular tone. The combination may add to hypotension, but a meaningful additive sedative effect is not well established.
What this interaction means in plain words
Papaverine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Papaverine belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive vasodilatory and hypotensive effects; no established sedative synergy.
What to do
Monitor blood pressure during propofol administration and titrate the dose to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Papaverine with Propofol?
MediHelp rates the interaction as minor. Papaverine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine is a vasodilator with minimal sedative properties, and propofol also lowers vascular tone. The combination may add to hypotension, but a meaningful additive sedative effect is not well established.
How serious is the interaction between Papaverine and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during propofol administration and titrate the dose to effect.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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