Drug interactions
Penicillin g + Pretomanid
Severity: Minor
Penicillin g and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits the renal organic anion transporter OAT3 in vitro, and penicillin G is eliminated mainly by tubular secretion through this pathway. Exposure to penicillin G could therefore rise modestly, but the clinical relevance has not been established and penicillin G has a wide therapeutic margin.
What this interaction means in plain words
Penicillin g and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Penicillin g belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of penicillin G by pretomanid, shown in vitro.
What to do
No routine dose change is needed. Watch for dose-related penicillin adverse effects such as neurotoxicity when high doses are given, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Penicillin g with Pretomanid?
MediHelp rates the interaction as minor. Penicillin g and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits the renal organic anion transporter OAT3 in vitro, and penicillin G is eliminated mainly by tubular secretion through this pathway. Exposure to penicillin G could therefore rise modestly, but the clinical relevance has not been established and penicillin G has a wide therapeutic margin.
How serious is the interaction between Penicillin g and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for dose-related penicillin adverse effects such as neurotoxicity when high doses are given, especially in renal impairment.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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