Drug interactions
Penicillin g + Vadadustat
Severity: Moderate
Penicillin g and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits renal organic anion transporter 3 (OAT3), which contributes to the tubular secretion of penicillin G. Exposure to penicillin G may therefore rise and its elimination half-life may lengthen. The clinical impact is usually modest, but it matters more at high doses or in renal impairment, where neurotoxicity is a concern.
What this interaction means in plain words
Penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Penicillin g belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits OAT3-mediated renal tubular secretion of penicillin G, reducing its clearance.
What to do
Monitor for penicillin-related adverse effects, especially neurotoxicity such as confusion or seizures at high doses. Consider reducing the penicillin G dose in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Penicillin g with Vadadustat?
MediHelp rates the interaction as moderate. Penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits renal organic anion transporter 3 (OAT3), which contributes to the tubular secretion of penicillin G. Exposure to penicillin G may therefore rise and its elimination half-life may lengthen. The clinical impact is usually modest, but it matters more at high doses or in renal impairment, where neurotoxicity is a concern.
How serious is the interaction between Penicillin g and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for penicillin-related adverse effects, especially neurotoxicity such as confusion or seizures at high doses. Consider reducing the penicillin G dose in patients with renal impairment.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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