Drug interactions
Pentamidine + Solifenacin
Severity: Major
Pentamidine and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine, especially when given intravenously, can prolong the QT interval and cause torsades de pointes. Solifenacin may add to this risk.
What this interaction means in plain words
Pentamidine and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pentamidine belongs to Anti Parasitic; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT interval prolongation.
What to do
Consider withholding solifenacin during systemic pentamidine therapy. If both are needed, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Pentamidine with Solifenacin?
MediHelp rates the interaction as major. Pentamidine and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentamidine, especially when given intravenously, can prolong the QT interval and cause torsades de pointes. Solifenacin may add to this risk.
How serious is the interaction between Pentamidine and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding solifenacin during systemic pentamidine therapy. If both are needed, monitor ECG and correct potassium and magnesium.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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