Drug interactions
Pentoxifylline + Zileuton
Severity: Moderate
Pentoxifylline and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentoxifylline and its metabolites are handled in part by CYP1A2, so zileuton may raise exposure. This could increase adverse effects such as nausea, dizziness, hypotension and bleeding tendency.
What this interaction means in plain words
Pentoxifylline and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pentoxifylline belongs to Cardiovascular; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, reducing pentoxifylline metabolism.
What to do
Monitor for gastrointestinal, vascular and bleeding adverse effects. Reduce the pentoxifylline dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
Frequently asked questions
Can I take Pentoxifylline with Zileuton?
MediHelp rates the interaction as moderate. Pentoxifylline and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentoxifylline and its metabolites are handled in part by CYP1A2, so zileuton may raise exposure. This could increase adverse effects such as nausea, dizziness, hypotension and bleeding tendency.
How serious is the interaction between Pentoxifylline and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal, vascular and bleeding adverse effects. Reduce the pentoxifylline dose if they occur.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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