Drug interactions
Perampanel + Ribociclib
Severity: Minor
Perampanel and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel is partly metabolized by CYP3A4, so ribociclib may modestly raise perampanel levels. This could increase dizziness, somnolence and psychiatric effects.
What this interaction means in plain words
Perampanel and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perampanel belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of perampanel by ribociclib.
What to do
Monitor for sedation, dizziness and mood changes during co-administration. Adjust the perampanel dose if adverse effects arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Perampanel with Ribociclib?
MediHelp rates the interaction as minor. Perampanel and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perampanel is partly metabolized by CYP3A4, so ribociclib may modestly raise perampanel levels. This could increase dizziness, somnolence and psychiatric effects.
How serious is the interaction between Perampanel and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and mood changes during co-administration. Adjust the perampanel dose if adverse effects arise.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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