Drug interactions
Perampanel + Tapentadol
Severity: Moderate
Perampanel and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel commonly causes dizziness, somnolence and impaired coordination, and can add to opioid CNS depression. It may also cause mood and behavioral changes that complicate assessment.
What this interaction means in plain words
Perampanel and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perampanel belongs to Central Nervous System; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects from AMPA-receptor antagonism and opioid action.
What to do
Monitor for sedation, ataxia and falls, particularly during perampanel titration. Counsel patients on driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Perampanel with Tapentadol?
MediHelp rates the interaction as moderate. Perampanel and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel commonly causes dizziness, somnolence and impaired coordination, and can add to opioid CNS depression. It may also cause mood and behavioral changes that complicate assessment.
How serious is the interaction between Perampanel and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and falls, particularly during perampanel titration. Counsel patients on driving and operating machinery.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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