Drug interactions
Perampanel + Voriconazole
Severity: Moderate
Perampanel and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, the main pathway for perampanel metabolism, and may increase perampanel concentrations. This can worsen dizziness, somnolence, ataxia, and mood or behavioral adverse effects.
What this interaction means in plain words
Perampanel and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perampanel belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by voriconazole decreases perampanel clearance.
What to do
Monitor for CNS adverse effects and psychiatric symptoms and reduce the perampanel dose if they develop. Reassess dosing when voriconazole is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Perampanel with Voriconazole?
MediHelp rates the interaction as moderate. Perampanel and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4, the main pathway for perampanel metabolism, and may increase perampanel concentrations. This can worsen dizziness, somnolence, ataxia, and mood or behavioral adverse effects.
How serious is the interaction between Perampanel and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and psychiatric symptoms and reduce the perampanel dose if they develop. Reassess dosing when voriconazole is discontinued.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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