Drug interactions
Perphenazine + Prochlorperazine
Severity: Major
Perphenazine and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two phenothiazine antipsychotics taken together add to QT prolongation and also to sedation, anticholinergic effects and extrapyramidal symptoms. There is no therapeutic benefit from the duplication.
What this interaction means in plain words
Perphenazine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perphenazine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac repolarizing potassium channels and duplicated dopamine D2 antagonism.
What to do
Avoid using both drugs together and keep to a single phenothiazine. If this is unavoidable, check the ECG and electrolytes and monitor for extrapyramidal effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Prochlorperazine?
MediHelp rates the interaction as major. Perphenazine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two phenothiazine antipsychotics taken together add to QT prolongation and also to sedation, anticholinergic effects and extrapyramidal symptoms. There is no therapeutic benefit from the duplication.
How serious is the interaction between Perphenazine and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both drugs together and keep to a single phenothiazine. If this is unavoidable, check the ECG and electrolytes and monitor for extrapyramidal effects.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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