Drug interactions
Perphenazine + Propofol
Severity: Moderate
Perphenazine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can potentiate the sedative and hypotensive effects of propofol. Lower anesthetic doses may be required and recovery may be prolonged.
What this interaction means in plain words
Perphenazine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and vasodilation through alpha-adrenergic and histaminergic blockade.
What to do
Titrate propofol carefully to effect and monitor blood pressure and respiration. Have airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Propofol
Frequently asked questions
Can I take Perphenazine with Propofol?
MediHelp rates the interaction as moderate. Perphenazine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine can potentiate the sedative and hypotensive effects of propofol. Lower anesthetic doses may be required and recovery may be prolonged.
How serious is the interaction between Perphenazine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol carefully to effect and monitor blood pressure and respiration. Have airway support available.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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