Drug interactions
Perphenazine + Vilazodone
Severity: Moderate
Perphenazine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a dopamine antagonist and its combination with vilazodone may increase the risk of neuroleptic malignant syndrome or serotonin toxicity. Perphenazine is also metabolised by CYP2D6, but vilazodone has little effect on it.
What this interaction means in plain words
Perphenazine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effect with dopamine D2 blockade, a pharmacodynamic interaction.
What to do
Monitor for hyperthermia, rigidity, tremor, clonus and autonomic instability when starting or adjusting either drug. Discontinue both and provide supportive care if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Vilazodone?
MediHelp rates the interaction as moderate. Perphenazine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a dopamine antagonist and its combination with vilazodone may increase the risk of neuroleptic malignant syndrome or serotonin toxicity. Perphenazine is also metabolised by CYP2D6, but vilazodone has little effect on it.
How serious is the interaction between Perphenazine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, tremor, clonus and autonomic instability when starting or adjusting either drug. Discontinue both and provide supportive care if toxicity develops.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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