Drug interactions
Phenobarbitone + Stiripentol
Severity: Moderate
Phenobarbitone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces enzymes that metabolise stiripentol and can lower its concentrations. Stiripentol also inhibits phenobarbital metabolism, so levels of the barbiturate can rise and cause sedation.
What this interaction means in plain words
Phenobarbitone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenobarbitone belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Phenobarbital induces CYP1A2, CYP3A4 and CYP2C19, while stiripentol inhibits CYP2C19 and other pathways, giving bidirectional pharmacokinetic effects.
What to do
Monitor seizure control, sedation and phenobarbital serum concentrations when starting or stopping either drug. Adjust doses of both agents according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Stiripentol
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Darolutamide + Phenobarbitone Major
- Finerenone + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
Frequently asked questions
Can I take Phenobarbitone with Stiripentol?
MediHelp rates the interaction as moderate. Phenobarbitone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces enzymes that metabolise stiripentol and can lower its concentrations. Stiripentol also inhibits phenobarbital metabolism, so levels of the barbiturate can rise and cause sedation.
How serious is the interaction between Phenobarbitone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control, sedation and phenobarbital serum concentrations when starting or stopping either drug. Adjust doses of both agents according to response.
What other medicines interact with Stiripentol?
MediHelp also lists interactions of Stiripentol with, for example, Apalutamide, Clomipramine, Ergotamine. The full list is on the Stiripentol page.
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