Drug interactions
Phentermine + Prochlorperazine
Severity: Moderate
Phentermine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic stimulant and prochlorperazine is a dopamine antagonist with sedating effects, so they may counteract one another. Both can affect heart rate and rhythm, adding arrhythmia risk in predisposed patients.
What this interaction means in plain words
Phentermine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phentermine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Opposing central monoaminergic effects with possible additive cardiac effects.
What to do
Monitor heart rate, blood pressure and efficacy, and consider ECG in patients with cardiac disease or QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Phentermine and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Phentermine with Prochlorperazine?
MediHelp rates the interaction as moderate. Phentermine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine is a sympathomimetic stimulant and prochlorperazine is a dopamine antagonist with sedating effects, so they may counteract one another. Both can affect heart rate and rhythm, adding arrhythmia risk in predisposed patients.
How serious is the interaction between Phentermine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and efficacy, and consider ECG in patients with cardiac disease or QT risk factors.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
