Drug interactions
Pomalidomide + Posaconazole
Severity: Moderate
Pomalidomide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is cleared partly by CYP3A4 and is a P-glycoprotein substrate, and posaconazole inhibits both pathways. Exposure may increase, with greater myelosuppression and other toxicity.
What this interaction means in plain words
Pomalidomide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pomalidomide belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 and P-glycoprotein, reducing pomalidomide clearance.
What to do
Monitor blood counts closely and watch for pomalidomide toxicity. Consider an alternative antifungal if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Posaconazole?
MediHelp rates the interaction as moderate. Pomalidomide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pomalidomide is cleared partly by CYP3A4 and is a P-glycoprotein substrate, and posaconazole inhibits both pathways. Exposure may increase, with greater myelosuppression and other toxicity.
How serious is the interaction between Pomalidomide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and watch for pomalidomide toxicity. Consider an alternative antifungal if toxicity develops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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