Drug interactions
Posaconazole + Ripretinib
Severity: Moderate
Posaconazole and Ripretinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise exposure to ripretinib and its active metabolite, potentially increasing adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
What this interaction means in plain words
Posaconazole and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Ripretinib belongs to Oncology.
Why it happens
Posaconazole inhibits CYP3A4, which metabolizes ripretinib and its active metabolite.
What to do
Monitor closely for ripretinib toxicity and interrupt or reduce the dose if adverse reactions develop; consider an alternative antifungal with less CYP3A4 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Posaconazole with Ripretinib?
MediHelp rates the interaction as moderate. Posaconazole and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can raise exposure to ripretinib and its active metabolite, potentially increasing adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
How serious is the interaction between Posaconazole and Ripretinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for ripretinib toxicity and interrupt or reduce the dose if adverse reactions develop; consider an alternative antifungal with less CYP3A4 inhibition.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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