Drug interactions
Posaconazole + Saxagliptin
Severity: Moderate
Posaconazole and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases exposure to saxagliptin and its active metabolite, which can increase dose-related adverse effects. Labeling advises limiting the saxagliptin dose with strong CYP3A4 inhibitors.
What this interaction means in plain words
Posaconazole and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Saxagliptin belongs to Endocrine.
Why it happens
Posaconazole inhibits CYP3A4/5-mediated metabolism of saxagliptin.
What to do
Limit saxagliptin to 2.5 mg once daily during posaconazole therapy. Monitor glycaemic control and for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Posaconazole with Saxagliptin?
MediHelp rates the interaction as moderate. Posaconazole and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole increases exposure to saxagliptin and its active metabolite, which can increase dose-related adverse effects. Labeling advises limiting the saxagliptin dose with strong CYP3A4 inhibitors.
How serious is the interaction between Posaconazole and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg once daily during posaconazole therapy. Monitor glycaemic control and for adverse effects.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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