Drug interactions
posaconazole + simvastatin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Rhabdomyolysis risk; contraindicated.
Mechanism of action
Strong CYP3A4 inhibition.
Clinical management
Contraindicated.
Drug reference
References
Frequently asked questions
Can I take posaconazole with simvastatin?
The interaction is rated: Contraindicated. Rhabdomyolysis risk; contraindicated.
How serious is the interaction between posaconazole and simvastatin?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between posaconazole and simvastatin managed?
Contraindicated.
Why do posaconazole and simvastatin interact?
Strong CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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