Drug interactions
Posaconazole + Sonidegib
Severity: Major
Posaconazole and Sonidegib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is a CYP3A4 substrate, and strong inhibitors raise its exposure. This may increase risks such as musculoskeletal toxicity and rhabdomyolysis.
What this interaction means in plain words
Posaconazole and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Posaconazole belongs to Anti Fungals; Sonidegib belongs to Oncology.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of sonidegib.
What to do
Avoid concomitant use with strong CYP3A4 inhibitors. If unavoidable, limit the duration and monitor creatine kinase and muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Posaconazole with Sonidegib?
MediHelp rates the interaction as major. Posaconazole and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sonidegib is a CYP3A4 substrate, and strong inhibitors raise its exposure. This may increase risks such as musculoskeletal toxicity and rhabdomyolysis.
How serious is the interaction between Posaconazole and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with strong CYP3A4 inhibitors. If unavoidable, limit the duration and monitor creatine kinase and muscle symptoms.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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