Drug interactions
Posaconazole + Tipranavir
Severity: Moderate
Posaconazole and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase tipranavir concentrations through CYP3A4 inhibition, but tipranavir is given with ritonavir, which already dominates CYP3A4 inhibition. Tipranavir may in turn affect posaconazole exposure through P-gp induction and UGT effects, which makes the net effect uncertain.
What this interaction means in plain words
Posaconazole and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tipranavir belongs to Anti Virals.
Why it happens
Mutual modulation of CYP3A4, P-gp and UGT pathways; the net effect is not well characterized.
What to do
Monitor tipranavir adverse effects, including liver enzymes, and consider checking posaconazole trough levels to confirm adequate antifungal exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Posaconazole with Tipranavir?
MediHelp rates the interaction as moderate. Posaconazole and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase tipranavir concentrations through CYP3A4 inhibition, but tipranavir is given with ritonavir, which already dominates CYP3A4 inhibition. Tipranavir may in turn affect posaconazole exposure through P-gp induction and UGT effects, which makes the net effect uncertain.
How serious is the interaction between Posaconazole and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tipranavir adverse effects, including liver enzymes, and consider checking posaconazole trough levels to confirm adequate antifungal exposure.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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