Drug interactions
Posaconazole + Upadacitinib
Severity: Moderate
Posaconazole and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases upadacitinib exposure, which may heighten the risk of infection and other JAK-inhibitor adverse effects. Labeling recommends dose reduction with strong CYP3A4 inhibitors.
What this interaction means in plain words
Posaconazole and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Upadacitinib belongs to Musculoskeletal.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces upadacitinib clearance.
What to do
Use the reduced upadacitinib dose recommended in labeling for strong CYP3A4 inhibitors and monitor for infection and other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Posaconazole with Upadacitinib?
MediHelp rates the interaction as moderate. Posaconazole and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole increases upadacitinib exposure, which may heighten the risk of infection and other JAK-inhibitor adverse effects. Labeling recommends dose reduction with strong CYP3A4 inhibitors.
How serious is the interaction between Posaconazole and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced upadacitinib dose recommended in labeling for strong CYP3A4 inhibitors and monitor for infection and other adverse effects.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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