Drug interactions
Pravastatin + Tucatinib
Severity: Minor
Pravastatin and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits intestinal P-glycoprotein and may raise the systemic exposure of P-gp substrates. Pravastatin is a modest P-gp substrate, so a small rise in exposure is possible, which could slightly increase the risk of statin-related muscle effects.
What this interaction means in plain words
Pravastatin and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-glycoprotein efflux, which may increase the intestinal absorption of pravastatin.
What to do
No routine dose change is needed; ask patients to report unexplained muscle pain or weakness. Check CK only if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Pravastatin with Tucatinib?
MediHelp rates the interaction as minor. Pravastatin and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits intestinal P-glycoprotein and may raise the systemic exposure of P-gp substrates. Pravastatin is a modest P-gp substrate, so a small rise in exposure is possible, which could slightly increase the risk of statin-related muscle effects.
How serious is the interaction between Pravastatin and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; ask patients to report unexplained muscle pain or weakness. Check CK only if symptoms develop.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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