Drug interactions
Pregabalin + Stiripentol
Severity: Moderate
Pregabalin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is a sedating antiseizure drug, and combining it with pregabalin can increase drowsiness, dizziness and ataxia. The interaction is mainly additive CNS effects, and both are often used in patients with epilepsy.
What this interaction means in plain words
Pregabalin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pregabalin belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Monitor for excessive sedation, ataxia and dizziness when starting or adjusting either drug. Reduce the dose if these effects become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Stiripentol
Frequently asked questions
Can I take Pregabalin with Stiripentol?
MediHelp rates the interaction as moderate. Pregabalin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is a sedating antiseizure drug, and combining it with pregabalin can increase drowsiness, dizziness and ataxia. The interaction is mainly additive CNS effects, and both are often used in patients with epilepsy.
How serious is the interaction between Pregabalin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, ataxia and dizziness when starting or adjusting either drug. Reduce the dose if these effects become troublesome.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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