Drug interactions
Pregabalin + Temsirolimus
Severity: Moderate
Pregabalin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin and temsirolimus can each be associated with angioedema, so the combination may raise the likelihood of swelling of the face, mouth and throat. Airway involvement can be serious.
What this interaction means in plain words
Pregabalin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pregabalin belongs to Central Nervous System; Temsirolimus belongs to Oncology.
Why it happens
Additive pharmacodynamic risk of angioedema; no pharmacokinetic mechanism is established.
What to do
Watch for early signs of swelling during infusions and while on pregabalin, and give emergency treatment if airway involvement develops. Consider an alternative to pregabalin if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Pregabalin with Temsirolimus?
MediHelp rates the interaction as moderate. Pregabalin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin and temsirolimus can each be associated with angioedema, so the combination may raise the likelihood of swelling of the face, mouth and throat. Airway involvement can be serious.
How serious is the interaction between Pregabalin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for early signs of swelling during infusions and while on pregabalin, and give emergency treatment if airway involvement develops. Consider an alternative to pregabalin if angioedema occurs.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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