Drug interactions
Pregabalin + Vortioxetine
Severity: Minor
Pregabalin and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes sedation, dizziness and cognitive slowing that may be additive with vortioxetine. Serious respiratory depression is chiefly a concern with opioids or in respiratory disease.
What this interaction means in plain words
Pregabalin and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pregabalin belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no meaningful pharmacokinetic interaction.
What to do
Titrate pregabalin gradually and counsel on sedation and driving. Monitor older or respiratory-compromised patients for excessive drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Pregabalin with Vortioxetine?
MediHelp rates the interaction as minor. Pregabalin and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pregabalin causes sedation, dizziness and cognitive slowing that may be additive with vortioxetine. Serious respiratory depression is chiefly a concern with opioids or in respiratory disease.
How serious is the interaction between Pregabalin and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate pregabalin gradually and counsel on sedation and driving. Monitor older or respiratory-compromised patients for excessive drowsiness.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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