Drug interactions
Prochlorperazine + Solifenacin
Severity: Moderate
Prochlorperazine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use may increase dry mouth, constipation, urinary retention, blurred vision and confusion, especially in older adults. Solifenacin has also been associated with QT prolongation at higher doses, which adds to the phenothiazine effect.
What this interaction means in plain words
Prochlorperazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Use the lowest effective doses and monitor for anticholinergic toxicity, particularly in elderly patients. Check ECG if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Solifenacin
Frequently asked questions
Can I take Prochlorperazine with Solifenacin?
MediHelp rates the interaction as moderate. Prochlorperazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use may increase dry mouth, constipation, urinary retention, blurred vision and confusion, especially in older adults. Solifenacin has also been associated with QT prolongation at higher doses, which adds to the phenothiazine effect.
How serious is the interaction between Prochlorperazine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for anticholinergic toxicity, particularly in elderly patients. Check ECG if other QT-prolonging risk factors are present.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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