Drug interactions
Prochlorperazine + Tacrolimus
Severity: Moderate
Prochlorperazine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining them may add to arrhythmia risk. Tacrolimus-related electrolyte changes such as hypomagnesemia and hyperkalemia may further increase this risk.
What this interaction means in plain words
Prochlorperazine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation, with tacrolimus-induced electrolyte disturbances contributing.
What to do
Monitor ECG and serum magnesium and potassium, especially in transplant patients on other QT-prolonging drugs. Use an alternative antiemetic if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Prochlorperazine with Tacrolimus?
MediHelp rates the interaction as moderate. Prochlorperazine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combining them may add to arrhythmia risk. Tacrolimus-related electrolyte changes such as hypomagnesemia and hyperkalemia may further increase this risk.
How serious is the interaction between Prochlorperazine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum magnesium and potassium, especially in transplant patients on other QT-prolonging drugs. Use an alternative antiemetic if risk factors are present.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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