Drug interactions
Prochlorperazine + Temazepam
Severity: Moderate
Prochlorperazine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so together they can cause greater drowsiness, impaired coordination and psychomotor impairment. Older adults are at particular risk of falls and confusion.
What this interaction means in plain words
Prochlorperazine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A enhancement by temazepam and antihistaminic and antidopaminergic sedation from prochlorperazine.
What to do
Use the lowest effective doses and monitor for oversedation, particularly in elderly patients. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Prochlorperazine with Temazepam?
MediHelp rates the interaction as moderate. Prochlorperazine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, so together they can cause greater drowsiness, impaired coordination and psychomotor impairment. Older adults are at particular risk of falls and confusion.
How serious is the interaction between Prochlorperazine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, particularly in elderly patients. Advise against driving and alcohol.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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