Drug interactions
Prochlorperazine + Tipranavir
Severity: Minor
Prochlorperazine and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, may inhibit CYP2D6 and CYP3A4 and raise prochlorperazine levels. This could increase sedation and extrapyramidal effects, though clinical data are lacking.
What this interaction means in plain words
Prochlorperazine and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prochlorperazine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Possible inhibition of CYP2D6 and CYP3A4 metabolism of prochlorperazine.
What to do
Monitor for sedation and extrapyramidal symptoms and lower the prochlorperazine dose if they develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Prochlorperazine and Tipranavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Prochlorperazine with Tipranavir?
MediHelp rates the interaction as minor. Prochlorperazine and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tipranavir, given with ritonavir, may inhibit CYP2D6 and CYP3A4 and raise prochlorperazine levels. This could increase sedation and extrapyramidal effects, though clinical data are lacking.
How serious is the interaction between Prochlorperazine and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and extrapyramidal symptoms and lower the prochlorperazine dose if they develop.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
