Drug interactions
Prochlorperazine + Trimethoprim
Severity: Moderate
Prochlorperazine and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine can prolong the QT interval, and trimethoprim has been linked to occasional QT prolongation and hyperkalemia. Together they may modestly add to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Prochlorperazine and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Trimethoprim belongs to Anti Bacterial.
Why it happens
Possible additive QT prolongation; the trimethoprim effect is not well characterized.
What to do
Obtain an ECG and check potassium and magnesium in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs. Choose an alternative antibiotic if QTc is markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Trimethoprim
Frequently asked questions
Can I take Prochlorperazine with Trimethoprim?
MediHelp rates the interaction as moderate. Prochlorperazine and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine can prolong the QT interval, and trimethoprim has been linked to occasional QT prolongation and hyperkalemia. Together they may modestly add to arrhythmia risk in susceptible patients.
How serious is the interaction between Prochlorperazine and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check potassium and magnesium in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs. Choose an alternative antibiotic if QTc is markedly prolonged.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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