Drug interactions
Prochlorperazine + Vorinostat
Severity: Moderate
Prochlorperazine and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may increase the risk of ventricular arrhythmias such as torsades de pointes. Vorinostat can also cause electrolyte disturbances and nausea that worsen this risk.
What this interaction means in plain words
Prochlorperazine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline and periodic ECGs, potassium, magnesium and calcium, and correct abnormalities. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Prochlorperazine with Vorinostat?
MediHelp rates the interaction as moderate. Prochlorperazine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may increase the risk of ventricular arrhythmias such as torsades de pointes. Vorinostat can also cause electrolyte disturbances and nausea that worsen this risk.
How serious is the interaction between Prochlorperazine and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs, potassium, magnesium and calcium, and correct abnormalities. Avoid adding further QT-prolonging drugs.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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