Drug interactions
Progesterone + Ribociclib
Severity: Minor
Progesterone and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise progesterone concentrations, since progesterone is metabolized by CYP3A4. The clinical effect is likely small and would mainly be progestogenic adverse effects such as sedation or breast tenderness.
What this interaction means in plain words
Progesterone and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Progesterone belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4-mediated metabolism of progesterone.
What to do
No dose adjustment is usually needed; watch for increased progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Progesterone with Ribociclib?
MediHelp rates the interaction as minor. Progesterone and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate CYP3A4 inhibitor and may raise progesterone concentrations, since progesterone is metabolized by CYP3A4. The clinical effect is likely small and would mainly be progestogenic adverse effects such as sedation or breast tenderness.
How serious is the interaction between Progesterone and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for increased progestogenic adverse effects.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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