Drug interactions
Progesterone + Sugammadex
Severity: Moderate
Progesterone and Sugammadex: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sugammadex can bind progesterone, which may reduce free hormonal levels and cause interference with serum progesterone assays. Hormonal contraceptive effectiveness may also be reduced for a short period after a dose.
What this interaction means in plain words
Progesterone and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Progesterone belongs to Endocrine; Sugammadex belongs to Miscellaneous.
Why it happens
Sugammadex encapsulates progestogens, lowering their free concentrations, similar to its binding of steroidal neuromuscular blockers.
What to do
Interpret serum progesterone results with caution after sugammadex. Counsel patients using hormonal contraception to follow the missed-dose advice for the product or use a non-hormonal backup method for 7 days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sugammadex
- Desogestrel-ethinyl estradiol + Sugammadex Moderate
- Ethinyl estradiol-drospirenone + Sugammadex Moderate
- Ethinyl estradiol-levonorgestrel + Sugammadex Moderate
- Etonogestrel + Sugammadex Moderate
- Levonorgestrel + Sugammadex Moderate
- Medroxyprogesterone + Sugammadex Moderate
Other interactions of Progesterone
Frequently asked questions
Can I take Progesterone with Sugammadex?
MediHelp rates the interaction as moderate. Progesterone and Sugammadex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sugammadex can bind progesterone, which may reduce free hormonal levels and cause interference with serum progesterone assays. Hormonal contraceptive effectiveness may also be reduced for a short period after a dose.
How serious is the interaction between Progesterone and Sugammadex?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interpret serum progesterone results with caution after sugammadex. Counsel patients using hormonal contraception to follow the missed-dose advice for the product or use a non-hormonal backup method for 7 days.
What other medicines interact with Sugammadex?
MediHelp also lists interactions of Sugammadex with, for example, Desogestrel-ethinyl estradiol, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Sugammadex page.
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