Drug interactions
Progesterone + Tipranavir
Severity: Moderate
Progesterone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir has a complex effect on CYP3A4 with net inhibition and may increase progesterone levels. Progestogenic adverse effects may be more frequent.
What this interaction means in plain words
Progesterone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Progesterone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4 metabolism of progesterone, although tipranavir also has inducing effects.
What to do
Monitor for sedation, dizziness and bleeding irregularities and adjust the progesterone dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Progesterone with Tipranavir?
MediHelp rates the interaction as moderate. Progesterone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir given with ritonavir has a complex effect on CYP3A4 with net inhibition and may increase progesterone levels. Progestogenic adverse effects may be more frequent.
How serious is the interaction between Progesterone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and bleeding irregularities and adjust the progesterone dose according to response.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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