Drug interactions
Propofol + Temazepam
Severity: Moderate
Propofol and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining propofol with temazepam increases sedation and may deepen the level of anesthesia more than expected. Respiratory depression and hypotension are possible, particularly in older or frail patients.
What this interaction means in plain words
Propofol and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Use a lower propofol dose and titrate slowly to the desired sedation level. Monitor respiration and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Propofol with Temazepam?
MediHelp rates the interaction as moderate. Propofol and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining propofol with temazepam increases sedation and may deepen the level of anesthesia more than expected. Respiratory depression and hypotension are possible, particularly in older or frail patients.
How serious is the interaction between Propofol and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower propofol dose and titrate slowly to the desired sedation level. Monitor respiration and blood pressure.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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