Drug interactions
Propofol + Ziconotide
Severity: Moderate
Propofol and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide given intrathecally commonly causes sedation, confusion and reduced consciousness, which may be potentiated by propofol. Greater sedation than expected is possible.
What this interaction means in plain words
Propofol and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression; ziconotide blocks N-type calcium channels while propofol potentiates GABA-A.
What to do
Use lower propofol doses and monitor level of consciousness and respiration. Review ziconotide dosing if excessive sedation persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Propofol and Ziconotide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propofol
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Propofol with Ziconotide?
MediHelp rates the interaction as moderate. Propofol and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide given intrathecally commonly causes sedation, confusion and reduced consciousness, which may be potentiated by propofol. Greater sedation than expected is possible.
How serious is the interaction between Propofol and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower propofol doses and monitor level of consciousness and respiration. Review ziconotide dosing if excessive sedation persists.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
