Drug interactions
Propylhexedrine + Trazodone
Severity: Minor
Propylhexedrine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant with indirect adrenergic activity. Trazodone may modify the pressor response, and combination may cause unpredictable blood pressure and heart rate changes. Systemic absorption at labeled doses is limited.
What this interaction means in plain words
Propylhexedrine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propylhexedrine belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Trazodone's adrenergic receptor effects may modify the response to an indirect sympathomimetic.
What to do
Use the inhaler only at labeled doses and for short periods. Monitor blood pressure in patients with cardiovascular disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Propylhexedrine with Trazodone?
MediHelp rates the interaction as minor. Propylhexedrine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propylhexedrine is an inhaled sympathomimetic decongestant with indirect adrenergic activity. Trazodone may modify the pressor response, and combination may cause unpredictable blood pressure and heart rate changes. Systemic absorption at labeled doses is limited.
How serious is the interaction between Propylhexedrine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inhaler only at labeled doses and for short periods. Monitor blood pressure in patients with cardiovascular disease.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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