Drug interactions
Ranolazine + Repotrectinib
Severity: Moderate
Ranolazine and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein and may modestly raise levels of P-gp substrates, but repotrectinib's reliance on P-gp is unclear. Repotrectinib is a CYP3A inducer which may lower ranolazine levels.
What this interaction means in plain words
Ranolazine and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Repotrectinib belongs to Oncology.
Why it happens
Repotrectinib induces CYP3A4, lowering ranolazine exposure; ranolazine may inhibit P-gp efflux of repotrectinib.
What to do
Avoid if possible because induction may reduce antianginal efficacy. Monitor angina control and repotrectinib adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Ranolazine with Repotrectinib?
MediHelp rates the interaction as moderate. Ranolazine and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein and may modestly raise levels of P-gp substrates, but repotrectinib's reliance on P-gp is unclear. Repotrectinib is a CYP3A inducer which may lower ranolazine levels.
How serious is the interaction between Ranolazine and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible because induction may reduce antianginal efficacy. Monitor angina control and repotrectinib adverse effects.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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