Drug interactions
Ranolazine + Risperidone
Severity: Moderate
Ranolazine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine may raise risperidone exposure through P-glycoprotein inhibition. Both drugs can prolong QTc, so the combination may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Ranolazine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus ranolazine inhibition of P-glycoprotein efflux of risperidone; ranolazine CYP2D6 inhibition may also contribute.
What to do
Monitor ECG and electrolytes, and watch for risperidone adverse effects such as sedation and extrapyramidal symptoms. Reduce the risperidone dose if these occur or QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Ranolazine with Risperidone?
MediHelp rates the interaction as moderate. Ranolazine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine may raise risperidone exposure through P-glycoprotein inhibition. Both drugs can prolong QTc, so the combination may increase the risk of ventricular arrhythmia.
How serious is the interaction between Ranolazine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for risperidone adverse effects such as sedation and extrapyramidal symptoms. Reduce the risperidone dose if these occur or QTc lengthens.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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