Drug interactions
Ranolazine + Ruxolitinib
Severity: Minor
Ranolazine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP3A4 inhibitor and ruxolitinib is a CYP3A4 substrate, so ruxolitinib exposure may rise slightly. This could increase cytopenias, though the effect is likely small.
What this interaction means in plain words
Ranolazine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Ruxolitinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by ranolazine reducing ruxolitinib metabolism.
What to do
No empiric dose change is needed. Monitor blood counts as routinely recommended for ruxolitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Ranolazine with Ruxolitinib?
MediHelp rates the interaction as minor. Ranolazine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine is a weak CYP3A4 inhibitor and ruxolitinib is a CYP3A4 substrate, so ruxolitinib exposure may rise slightly. This could increase cytopenias, though the effect is likely small.
How serious is the interaction between Ranolazine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor blood counts as routinely recommended for ruxolitinib.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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