Drug interactions
Ranolazine + Stiripentol
Severity: Moderate
Ranolazine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so its effect on ranolazine exposure is unpredictable. Higher ranolazine levels could increase dose-related adverse effects and QT prolongation, while induction could reduce antianginal efficacy.
What this interaction means in plain words
Ranolazine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction plus P-glycoprotein inhibition by stiripentol alter ranolazine absorption and clearance.
What to do
Monitor anginal control, tolerability and the ECG when stiripentol is started or stopped. Adjust the ranolazine dose according to response and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Ranolazine with Stiripentol?
MediHelp rates the interaction as moderate. Ranolazine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so its effect on ranolazine exposure is unpredictable. Higher ranolazine levels could increase dose-related adverse effects and QT prolongation, while induction could reduce antianginal efficacy.
How serious is the interaction between Ranolazine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor anginal control, tolerability and the ECG when stiripentol is started or stopped. Adjust the ranolazine dose according to response and adverse effects.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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