Drug interactions
Ranolazine + Tramadol
Severity: Minor
Ranolazine and Tramadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP2D6 inhibitor and may modestly reduce activation of tramadol to its active opioid metabolite while raising parent tramadol levels. The clinical effect is generally small.
What this interaction means in plain words
Ranolazine and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Tramadol belongs to Musculoskeletal.
Why it happens
Weak CYP2D6 inhibition by ranolazine alters tramadol metabolism.
What to do
No routine adjustment is needed; watch for reduced analgesia or serotonergic symptoms if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Tramadol?
MediHelp rates the interaction as minor. Ranolazine and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine is a weak CYP2D6 inhibitor and may modestly reduce activation of tramadol to its active opioid metabolite while raising parent tramadol levels. The clinical effect is generally small.
How serious is the interaction between Ranolazine and Tramadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for reduced analgesia or serotonergic symptoms if the response changes.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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