Drug interactions
Ranolazine + Triclabendazole
Severity: Moderate
Ranolazine and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole has been associated with QT prolongation, and ranolazine also prolongs the QT interval. Combined use may increase the risk of arrhythmia, especially in patients with other risk factors.
What this interaction means in plain words
Ranolazine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QT interval prolongation.
What to do
Obtain an ECG before treatment in patients with cardiac disease or electrolyte abnormalities. Correct potassium and magnesium and consider temporarily withholding ranolazine during the short triclabendazole course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Ranolazine with Triclabendazole?
MediHelp rates the interaction as moderate. Ranolazine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole has been associated with QT prolongation, and ranolazine also prolongs the QT interval. Combined use may increase the risk of arrhythmia, especially in patients with other risk factors.
How serious is the interaction between Ranolazine and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before treatment in patients with cardiac disease or electrolyte abnormalities. Correct potassium and magnesium and consider temporarily withholding ranolazine during the short triclabendazole course.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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