Drug interactions
Ranolazine + Valbenazine
Severity: Moderate
Ranolazine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and ranolazine also prolongs QT. Combined use may add to the risk of arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Ranolazine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and correct electrolyte abnormalities in at-risk patients. Avoid adding further QT-prolonging drugs and limit valbenazine dose in those with CYP2D6 or CYP3A4 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Ranolazine with Valbenazine?
MediHelp rates the interaction as moderate. Ranolazine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and ranolazine also prolongs QT. Combined use may add to the risk of arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Ranolazine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct electrolyte abnormalities in at-risk patients. Avoid adding further QT-prolonging drugs and limit valbenazine dose in those with CYP2D6 or CYP3A4 inhibition.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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