Drug interactions
Regorafenib + Tenofovir alafenamide
Severity: Minor
Regorafenib and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit the efflux transporter BCRP, and tenofovir alafenamide is a substrate of intestinal efflux transporters including P-gp and BCRP. Absorption of tenofovir alafenamide could therefore increase, although the clinical significance is uncertain.
What this interaction means in plain words
Regorafenib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Regorafenib belongs to Oncology; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Inhibition of BCRP by regorafenib may increase the systemic exposure of tenofovir alafenamide.
What to do
No dose change is usually needed; monitor for tenofovir-related adverse effects, particularly renal function, during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Regorafenib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib may inhibit the efflux transporter BCRP, and tenofovir alafenamide is a substrate of intestinal efflux transporters including P-gp and BCRP. Absorption of tenofovir alafenamide could therefore increase, although the clinical significance is uncertain.
How serious is the interaction between Regorafenib and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for tenofovir-related adverse effects, particularly renal function, during combined use.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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